Scientific Program
-
2:00PM - 2:05PM EST
Welcome
Alexander Krupnick, University of Maryland Medical System
Dr. Krupnick is the chief of thoracic surgery at the University of Maryland School of Medicine with an academic and clinical focus dedicated to the care of patients with end-stage lung failure and oncologic disease. He provides a full range of thoracic surgery services, including minimally invasive lung and esophageal resections, on the University of Maryland Medical School main campus as as affiliated hospitals. His laboratory has made seminal contributions toward the understanding lung transplant immunology, including the development of the world’s first model of vascularized orthotopic lung transplantation in the mouse (PMC3848695). He has also described numerous mechanistic aspects of lung allograft tolerance and rejection including the role of CD8+ T cells and eosinophils in mediating lung allograft tolerance (PMC3938255, PMC6629120). In addition to work on transplantation my laboratory has focused extensive efforts on understanding and reversing immunological dysfunction associated with cancer. His laboratory has made contributions in describing the role of natural killer cells in controlling lung cancer development and progression (PMID: 22751136), as well as advancing the understanding of immunological factors that limit natural killer cell function in malignancies (PMID: 30381460, 28123874). Based this understanding he has developed a rationally designed retargeted cytokine to activate natural killer cells and CD8+ cytotoxic lymphocytes (PMID: 27650575). These efforts are now being advanced toward human applications with an IND application in progress, GMP drug production initiated, and clinical trials planned for summer of 2022.Pavan Atluri, Thomas Jefferson University
Dr. Atluri is Director of Mechanical Circulatory Support and Heart Transplant and Director of Minimally Invasive and Robotic Cardiac Surgery at the University of Pennsylvania.
-
2:05PM - 2:30PM EST
Critical History and Importance of Surgical Research, "AKA the pep talk"
Alexander Krupnick, University of Maryland Medical System
Dr. Krupnick is the chief of thoracic surgery at the University of Maryland School of Medicine with an academic and clinical focus dedicated to the care of patients with end-stage lung failure and oncologic disease. He provides a full range of thoracic surgery services, including minimally invasive lung and esophageal resections, on the University of Maryland Medical School main campus as as affiliated hospitals. His laboratory has made seminal contributions toward the understanding lung transplant immunology, including the development of the world’s first model of vascularized orthotopic lung transplantation in the mouse (PMC3848695). He has also described numerous mechanistic aspects of lung allograft tolerance and rejection including the role of CD8+ T cells and eosinophils in mediating lung allograft tolerance (PMC3938255, PMC6629120). In addition to work on transplantation my laboratory has focused extensive efforts on understanding and reversing immunological dysfunction associated with cancer. His laboratory has made contributions in describing the role of natural killer cells in controlling lung cancer development and progression (PMID: 22751136), as well as advancing the understanding of immunological factors that limit natural killer cell function in malignancies (PMID: 30381460, 28123874). Based this understanding he has developed a rationally designed retargeted cytokine to activate natural killer cells and CD8+ cytotoxic lymphocytes (PMID: 27650575). These efforts are now being advanced toward human applications with an IND application in progress, GMP drug production initiated, and clinical trials planned for summer of 2022. -
2:30PM - 3:00PM EST
The Chair/Dean/CEO Perspective on CT Surgeons' Involvement in Biomedical Research
-
3:00PM - 7:00PM EST
Session I: Sources of Surgical Funding
-
7:00PM - 8:00PM EST
Session II: Mock Study Section
-
8:00PM - 9:00PM EST
-
9:00PM - 10:00PM EST
Cocktail Hour and Networking