Dr. Ono was graduated from the University of Tokyo, Japan in 1987. He underwent surgical residency at the Social Security General Hospital. He started Cardiothoracic residency at the University of Tokyo Hospital, and entered the cardiothoracic fellowship program at Asahi General Hospital. He went abroad to the Ohio State University Medical Center to have advanced fellowship training of Cardiothoracic Surgery (minimally invasive surgery and heart transplantation) from 1999 to 2001.
After he came back to the Department of Cardiovascular Surgery at the University of Tokyo as a staff surgeon, he established a program of surgery for advanced heart failure at the hospital. He was promoted to the Lecturer in 2004, and was appointed as Chief and Professor, Department of Cardiovascular Surgery, The University of Tokyo Hospital in 2009. He actively participated in a cooperative development program of the medial devices with School of Engineering at The University of Tokyo and some companies (endoscopic surgical manipulators and an innovative suture device which eliminates knot tying in cardiac surgery). He was co-appointed as Professor at Research Institute for Biomedical Science and Engineering at The University of Tokyo in 2017.
He has been actively involved in the academic and social activities of major medical societies as a Board Member, such as Japan Surgical Society, Japanese Society for Cardiovascular Surgery, Japanese Association for Thoracic Surgery, Japanese Circulation Society and Japanese Society for Transplantation. He is also a member of many world-leading societies, such as AATS, STS, EACTS, ISHLT, TTS and ASCVTS.